KIDNEY FUNCTION AND SOME HEAVY METALS STATUS OF LEATHER TANNERS AT MAJEMA TANNERY, KOFAR WAMBAI, KANO STATE- NIGERIA.

AISHA MUHAMMAD GADANYA, R. D. Maiwada, A. M. Wudil, A. A. Iman

Abstract


Leather tanners are exposed to toxic chemicals and heavy metals that may be harmful to their health. The present study was aimed at assessing the effect of tanning processes on renal function and some heavy metals status of leather tanners at Majema Tannery Kofar Wambai, Kano. Sixty (60) apparently healthy male individuals were divided into four groups of 15 persons each (i.e control group obtained from Dorayi-Gwale Local Government, non - tanners residing near the tannery but do not participate in the work, moderate tanners with working experience of 0- 10 years and heavy tanners with working experience of 10 years and above).   Some kidney function  parameters in serum (urea, creatinine and electrolytes i.e Na,  K+, Cl- and HCO3-), and in urine (albumin and creatinine), serum vitamin D and Lactate Dehydrogenase activities (using NAD as a substrate) were measured by spectrophotometric method. Serum levels of some heavy metals (chromium, cadmium and zinc) were measured using atomic absorption spectrometry. Systolic and diastolic blood pressures were measured using sphygmomanometer. There was significant increase in albuminuria in all the four groups and lactate dehydrogenase for the heavy tanners (p>0.05), while serum vitamin D was within normal range. Both heavy and moderate tanners had significantly (p<0.05) higher serum chromium and cadmium than control, and non-tanners. Systolic and diastolic blood pressures for all the four groups were within normal range. Thus, there is possibility of renal impairment, if not now, but in the near future for the tanners.

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Abid, O., Sun, Q., Sugimoto, K., Mercan, D. and Vincent, J. L., (2001). “Predictive value of microalbuminuria in medical ICU Patients: Results of a pilot study”.Chest. 120(6): 1984-8.

Berthelot’s Reaction (1967).Chaney, A.L., and Marbach, E.P. “Modified reagents for the determination of urea and ammonia”.Clinical Chem., 8:130-132.

Bolland, M.J., Grey, A., Gamble, G.D. and Reid, I.R. (2014). “Vitamin D supplementation Fals: a trial sequential meta-analysis”.Lancet Diabetes Endocrinol. 2(7):573-80.

Carmen A.P., Mary A.W., Joachin H.I., Michael G.S., (2009).”Kidney Function and Systolic Blood Pressure New Insights from Cystatin C: Data from Heart and Soul study. “PMC, US. National Library of Medicine, National Institute of Health.

Cot, J. Marsal, A., Manich, A., Celma, P., Choque, R., Cabeza, L., Labastida, L., Lopez, J., Salmeron, J. (2003). ”Mininmisation of industrial wastes: Adding value to collagen materials.” J.soc, leather technol chem., 87: 97-99.

Doumas, B.T., Watson, W.A. and Biggs, H.G .(1971). “Methods of Measuring Serum/ Urine Albumin.”Clin.Chem. Acta.31: 87.

Esterez, J.E., Baquero, E., and Rodrigues, R. (2008). “Anaerobic performance when rehydrating with water or commercially available sports drinks during prolonged exercise in the heat.” Applied Physiolgy, Nutrition and Metabolism. 33(2):290-298.

Heidmann, E. (2005).‘Leather’.Ullmanns Encyclopedia of industrial Chemistry. London Boomerang Press.Pp: 63-85.

Henry, J.B. (2001). “Clinical diagnosis and management of laboratory methods. 20th ed. Philadelphia. W.B. Saunders company.

Holmes, R. S., and Goldberg, E. (2009). “Computational analysis of mammalian lactate dehydrogenase: Human, mouse, opossum and platypus LDHs.” Computational Biology and Chemistry. 33 (5): 379-85.

Iwalokun BA, Ogunfemi MK, Gbajabiamila B, Olukosi YA, (2006).“Incidence and Evaluation of risk factors of microalbuminuria among diabetes and non- diabetes in Lagos, Nigeria.”Nig J, Health and Biomed Sci; 5(1) 7-8.

Jaffe, H.R., Cannon, C.D., Winkelman, W.J.(1964). “Clinical Chemistry, Jaffe’s Method”. 3rd Edition, Harper and Row Hagerstown, Cambridge: 543.

Jorge LG, Mirela JD, Sandra PS, Lu´is HC, Maria LC, Themis Z (2005).“ Diabetic Nephropathy: Diagnosis, Prevention, and Treatment. “Diabetes Care; 28:176 –188.

Kamil, P., Regina, B., Jaroslaws, T., Aldona, Z. and Wladyslaw, W. (2011). “The effect of addictive of lewis acid type on lithium-gel electrolyte characteristics”.ElectrochemicalActa.57: 58-65.

Langmaier, F., Kolomaznik, K., Sukop, S. and Maldek, M. (1999). “Products of enzymatic decomposition of chrome tannedleather wastes”.J Soc leather technol chem, 83(1):187-195.

Levey, A.S. and Coresh, J. (2012). “Chronic kidney diseases”. Lancet. 379: 165-180.

Li, Y., Lin, G., Lin, C., Wang, J., Han, C. (2013). “Relation of estimated GFR and BMI to mortality in non dialysis patients with coronary artery diseases: A report from the ET- CHD registry, 1997-2003. Journal of Cardiology. 62 (3): 144-150.

McWilliam A., Suraj T., Ross M., (2009). Laboratory tests of renal function. Anaesthesia & Intensive Care.The urea cycle.Medicine ; 10, 6: 296-99.9. Watford M.

Mehta, A.R. (2008). “Why does the plasma urea concentrations increase in acute dehydration?”Advances in physiology education: 32(4). Pp 336.

Nankivell, B.J. (2001). “Craetinine clearance and the assessment of renal function. Aust prescr. 24: 15-7.

Oramasionwu, G.E., Thacher, T.D., Pam, S.D., Pettifor, J.M, Abrams, S.A. (2008). “Adaptation of calcium absorption during treatment of nutritional rickets in Nigerian childen”. The British journal of nutrition. 100(2): 387-92.

Parving, H.H., Lemert, H., Brochner-Mortensen, J., Gomis, R., Andersen, S. and Arner, P., (2001).“The effect of irbesertan on the development of diabetic nephropathy in patients with type 2 diabetes.”N. England. J., Med. 345(12):870-8.

Ramasami, T. (2001). “Approach towards aunifiedtheory for tanning: Wilson’s dream. J. Am leather chem. Assoc, 96: 290-304.

Reemtsma, A. and Jekel, J., (1997). “Dissolved organics in tannery waste waters and their alteration by a combined anaerobic and aerobic treatment.” Water research, 31 (5): 1035-1046.

Roche Diagnostics International Ltd (2012). “ Elecsys® Vitamin D total assay Electro-chemiluminescence binding assay (ECLIA) for the in-vitro determination of total 25-hydroxyvitamin D”. Rotkreuz, Switzerland.


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