Field trials were conducted in 2016 and 2017 dry season in the Teaching and Research Farm of the Department of Crop Protection Faculty of Agriculture University of Maiduguri to assess the effect of seedling damping-off and wiltsdiseaseof sesame in Maiduguri. The sesame cultivars used were; E8, Ex-Sudan, NCRIBEN-04E, NCRIBEN-01M, NCRIBEN-05E and NCRIBEN-03L. The In-vitro experiments was laid in a complete randomize design (CRD), while the field trials were laid out in a Randomized Complete Block Design replicated three times. Results showed that in the In-vitro study,Fusariumoxysporum, F.solani, RhizoctoniasolaniAspergillusniger and Alternaria spp. were responsible for seedling damping-off and wilts diseases of irrigated sesame in Maiduguri. Field trials showed that Ex-Sudan had the highest seedling emergence, and it flowered earlier than all the other cultivars. Percentage pre-emergence and post-emergence damping-off and wilts diseases of sesame were also lower in Ex-Sudan and NCRIBEN-04E, higher incidence of seedling damping-off and wilts disease of sesame were observed in NCRIBEN-01M, NCRIBEN-03L and E8 respectively. Seed yield and yield components were significantly (P<0.05)higher in Ex-Sudan, NCRIBEN-04E, and NCRIBEN-05E. Fusarium spp. were found to be in constant association with irrigated sesame seedling damping-off and wilts disease of sesame in Maiduguri.There is the need for introduction of some locally high yielding sesame cultivars to the resource-poor farmers, also farmers are to be encouraged to treat their seed before sowing to manage damping-off and wilts diseases of irrigated sesame.

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